AV俱乐部

Dr. Brendan Leung is a biomedical engineer and received his undergraduate training in biochemistry and chemical engineering from the University of Ottawa. He began his research career as an undergraduate trainee, investigating the roles of XIAP in ovarian cancer chemoresistance in Dr. Benjamin Tsang鈥檚 lab. He earned his Master鈥檚 and Doctorate in biomedical engineering from the University of Toronto, supervised by Dr. Michael Sefton and specializing in cardiac tissue regeneration. Later, Dr. Leung joined Dr. Shuichi Takayama鈥檚 group at the University of Michigan to investigate polymeric liquid scaffolds for host-microbe co-culture systems. In 2016, Dr. Leung started his research group at AV俱乐部, and in 2022, he was promoted to associate professor (with tenure) and received the AV俱乐部 President鈥檚 Research Excellence Award. His current research program focuses on the development of advanced tissue construct platforms and assay technologies to understand fundamental phenomenon that govern tissue homeostasis and maladaptation in human diseases. Specifically, he is interested in creating in vitro tools to understand the role of human associated microbes in chronic disease, including metabolic diseases, fibrosis, and cancer. His multidisciplinary research group at AV俱乐部 focuses on combining multiple tissue components, including epithelium, mesenchyme, immune cells, and microbial colonies in minimalistic fashions to recapitulate tissue level phenomenon, while maintaining the ability to gather meaningful measurements. The group is also invested in the creation and/or adaptation of cutting-edge methods to perturb these engineered tissue models to facilitate biomedical research.