AV俱乐部

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Education

BSc (University of King鈥檚 College)
MSc (AV俱乐部)
PhD (Swiss Federal Institute of Technology (ETHZ))

Research Interests

I would like to understand the brain functions required to engage in normal peer-to-peer social interactions. For this, my laboratory uses a combination of epigenetic and neuroconnectivity approaches to (1) identify neural circuits required for appropriate social engagement, and (2) understand how epigenetic regulation affects functional connectivity within these circuits. Our research is relevant for social-related disorders like autism spectrum disorder and social anxiety disorder.

Selected Publications

• Spiteri R, Hartley MR, Yang JR, Franklin TB (2023). Differential expression of Hdac2 in male and female mice of differing social status. Physiology and Behavior. 273, 114406. doi:听
• Kosel F, Hartley MR, Franklin TB (2023). Aberrant cortical activity in 5xFAD mice in response to social and non-social olfactory stimuli. Journal of Alzheimer鈥檚 Disease. 97(2), 659-77. doi:听
  
• Torres Mu帽oz P, Franklin TB (2022). The anxiogenic effects of adolescent psychological stress in male and female mice. Behavioural Brain Research.听 432, 113963.听
  
• Kosel F,听Hamilton J,听Harrison S,听Godin V,听Franklin TB听(2021).听Reduced social investigation and increased injurious behaviour in听transgenic听5xFAD mice. Journal of Neuroscience Research. 99, 209-22.听doi:.听Associated Published Dataset: 鈥�5xFAD听mice听in their home-cage, the three-chamber sociability test and free social interaction task鈥澨�
• Kosel, F,听Pelley, JMS,听Franklin, TB听(2020). Behavioural and psychological symptoms of dementia听in mouse models of Alzheimer鈥檚 disease. Neuroscience and Biobehavioral Reviews 112: 634-47.听doi:听.
• Wheeler RV,听Franklin TB听(2019).听The听importance听of the epigenome for social-related neural circuits.听Epigenomics. 11, 1557-1560.听.
• Kosel F,听Torres Munoz P, Yang JR, Wong AA,听Franklin, TB听(2019).听Age-related changes in social behaviours in the 5xFAD mouse model of Alzheimer's disease. Behavioural Brain Research. 362, 160-72. Doi:听.听 Associated Published Dataset: "Social behaviours in the 5xFAD mouse"听.
• Franklin TB, Silva BA,听Perova听Z, Marrone L, Masferrer ME, Zhan Y,听Kaplan A,听Greetham L,听Verrechia V,听Halman A,听Pagella S, Vyssotski AL, Illarionova A, Grinevich V, Branco T, Gross CT (2017). Prefrontal cortical control of a brainstem social behavior circuit. Nature Neuroscience. 20, 260-70.听 Doi:听.听

Teaching

NESC/PSYO 3161 Measuring Behaviour
NESC 4007 Contemporary Issues in Neuroscience

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